Intra-amygdala administration of polyamines modulates fear conditioning in rats.
J Neurosci
; 24(9): 2328-34, 2004 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-14999084
ABSTRACT
Amygdalar NMDA receptor activation has been implicated in the acquisition of fear memories in rats. However, little is known about the role of endogenous modulators of the NMDA receptor, such as polyamines, in pavlovian fear-conditioning learning. Therefore, in the present study we investigated whether the immediate pretraining or post-training bilateral infusion of arcaine, an antagonist of the NMDA receptor polyamine-binding site, or spermidine, an agonist of the NMDA receptor polyamine-binding site, into the amygdala affected classical fear conditioning in rats. Bilateral microinjections of arcaine (0.0002-0.2 nmol) decreased, whereas spermidine (0.002-20 nmol) increased, contextual and auditory fear conditioning. Arcaine coadministration, at a dose that had no effect per se, reversed the facilitatory effect of spermidine. These results provide evidence that endogenous and exogenous polyamines modulate the acquisition or early consolidation (or both) of the fear-conditioning task in the amygdala.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliaminas Biogênicas
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Condicionamento Clássico
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Medo
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Tonsila do Cerebelo
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil