Protease mutations in HIV-1 non-B strains infecting drug-naive villagers in Cameroon.
AIDS Res Hum Retroviruses
; 20(1): 105-9, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-15008125
ABSTRACT
To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
População Rural
/
Infecções por HIV
/
Protease de HIV
/
HIV-1
/
Fármacos Anti-HIV
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos