Effects of vinclozolin on spermatogenesis and reproductive success in the Japanese quail (Coturnix coturnix japonica).
Arch Environ Contam Toxicol
; 46(4): 528-33, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15253051
ABSTRACT
In a one-generation reproduction study, the major agricultural fungicide vinclozolin was administered to adult Japanese quail for a period of 6 weeks at dietary levels of 125 and 500 ppm. Fertility and reproductive performance were not affected up to the highest concentration, although the examination of additional endpoints in the drakes (spermatid count, histology of the testis) provided some evidence of an inhibition of spermatogenesis at both dietary concentrations. Likewise, there were no indications of systemic toxicity in the adult birds. Plasma hormone concentrations (estradiol, testosterone, progesterone, T3, and T4) showed a large interindividual variance but treatment-related differences between the groups could not be established. There were no clear-cut indications of antiandrogenic effects in quail, although a limited transfer of the test substance into the eggs was proven.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxazóis
/
Espermatogênese
/
Coturnix
/
Poluentes Ambientais
/
Fertilidade
Limite:
Animals
Idioma:
En
Revista:
Arch Environ Contam Toxicol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha