Steroid- and ATG-resistant rejection after double forearm transplantation responds to Campath-1H.
Am J Transplant
; 4(8): 1372-4, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15268743
ABSTRACT
We herein report on immunological and histological observations in the first bilateral forearm transplant recipient. The last of three rejection episodes occurring on day 95 after transplantation was resistant to steroid and antithymocyte globulin (ATG) treatment. Histology demonstrated lymphocytic infiltrates, apoptotic and necrotic keratinocytes and focal desquamation of the epidermis. Therapy with Campath-1H, however, resulted in complete restitution of normal skin. This is the first report on a successful rescue therapy with Campath-1H in a severe, steroid- and ATG-resistant rejection. Hence, Campath-1H treatment might be a novel and powerful therapeutic option for multiresistant allograft rejection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Transplante Homólogo
/
Resistência a Medicamentos
/
Transplante de Órgãos
/
Antebraço
/
Rejeição de Enxerto
/
Imunossupressores
/
Anticorpos Monoclonais
/
Anticorpos Antineoplásicos
/
Soro Antilinfocitário
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Áustria