[Statins for treatment of CNS diseases. Status report from research and clinical practice]. / Statine zur Behandlung von Erkrankungen des zentralen Nervensystems. Eine Standortbestimmung aus Forschung und Klinik.
Nervenarzt
; 76(4): 426-37, 2005 Apr.
Article
em De
| MEDLINE
| ID: mdl-15448914
ABSTRACT
3-Hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, "statins," are widely used oral cholesterol-lowering drugs. Statins competitively inhibit HMG-CoA reductase, the enzyme that catalyzes conversion of HMG-CoA to L-mevalonate, a key intermediate in cholesterol synthesis. Certain metabolites of L-mevalonate are also involved in posttranslational modifications of specific proteins with cell proliferation and differentiation properties. Thus, statins have important biologic effects beyond their cholesterol-reducing properties. Here we discuss recent experimental and clinical data that may support a potential role for statins in the treatment of three central nervous system (CNS) neurological diseases Multiple sclerosis (MS), Alzheimer's disease (AD), and ischemic stroke. Despite their considerable pathogenic differences, in animal models of these disorders statins have shown beneficial effects. In both stroke and AD cohort studies suggest a beneficial treatment effect in humans; in MS, results from small open-label studies look encouraging. Multicenter, randomized, placebo-controlled clinical trials are in the planning or recruiting stage to evaluate the therapeutic effects of statins in all three disorders.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Padrões de Prática Médica
/
Encefalopatias
/
Ensaios Clínicos como Assunto
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Pesquisa Biomédica
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Humans
Idioma:
De
Revista:
Nervenarzt
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos