Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.
Bioorg Med Chem Lett
; 14(22): 5537-42, 2004 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-15482919
ABSTRACT
A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Quimiocinas
/
Lactamas
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos