Long-term immunity to poliovirus after vaccination of allogeneic stem cell transplant recipients.
Bone Marrow Transplant
; 34(12): 1067-9, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15489876
ABSTRACT
Revaccination with poliovirus after allogeneic stem cell transplant (SCT) is usually effective, but the longevity of this immunity is unknown. Therefore, poliovirus immunity was studied in 134 patients having survived at least 5 years after vaccination. The median follow-up from vaccination was 8 years (1-19 years). In all, 21 (15.6%) patients had become seronegative to at least one of the poliovirus serotypes during follow-up. The estimated probabilities of remaining immune to poliovirus at 5 and 10 years after vaccination were 94 and 94% for subtype 1, 98 and 94% for subtype 2, and 93 and 90% for subtype 3, respectively. In multivariate analysis, the only risk factor for loss of immunity was younger patient age (P < 0.01), and there was a strong trend for patients with chronic GVHD to lose immunity more rapidly (P = 0.07). A total of 14 patients received a booster dose of an inactivated poliovirus vaccine and all responded. We conclude that poliovirus immunity is retained long term after revaccination in most patients after allogeneic SCT.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliomielite
/
Vacinação
/
Neoplasias Hematológicas
/
Poliovirus
/
Imunidade
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
/
Child
/
Child, preschool
/
Humans
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Infant
/
Middle aged
Idioma:
En
Revista:
Bone Marrow Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Suécia