Does tibolone affect serum leptin levels and body weight in postmenopausal women?
Arch Gynecol Obstet
; 272(2): 127-30, 2005 Jul.
Article
em En
| MEDLINE
| ID: mdl-15517326
ABSTRACT
OBJECTIVES:
Leptin has a significant role in body weight regulation and energy balance. We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women. STUDYDESIGN:
Twenty women (aged 43-60 years) participated in this prospective study. All women in this study protocol received 2.5 mg/day of tibolone. Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy.RESULTS:
Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment. A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67).CONCLUSIONS:
Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women. There is a significant correlation between serum leptin levels and BMI values.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
/
Pós-Menopausa
/
Moduladores de Receptor Estrogênico
/
Leptina
/
Norpregnenos
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Arch Gynecol Obstet
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Turquia