[Mechanism of intracerebral calcification in hypoparathyroidism].
Clin Calcium
; 14(6): 55-7, 2004 Jun.
Article
em Ja
| MEDLINE
| ID: mdl-15577055
ABSTRACT
The mechanism of intracranial calcification in hypoparathyroidism, more frequently seen in pseudo--than idiopathic hypoparathyroidism, has not been completely elucidated, but may be related more to the duration of hypocalcaemia and hyperphosphatemia than parathyroid hormone itself. Hyperphosphatemia promotes ectopic calcification, especially in blood vessel and periarticular tissue in renal failure, but in brain tissue in hypoparathyroidism. Participation of PTH receptor2 in the brain and superoxide production by mitochondria in hypoparathyroidism should be explored with reference to intracerebral calcification and neurodegenerative diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Calcinose
/
Pseudo-Hipoaldosteronismo
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Ja
Revista:
Clin Calcium
Assunto da revista:
METABOLISMO
Ano de publicação:
2004
Tipo de documento:
Article