Interpretation of two-stage experiments in animal studies.
Lab Anim
; 39(1): 75-9, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15703127
ABSTRACT
Two-stage experiments allow results to be analysed at the end of the first stage and the second stage to be omitted if the preliminary conclusions are clear-cut. They thus offer the potential to reduce the number of experimental animals. However, using standard P values to assess the significance of results at the end of either stage will lead to an increase in risk of false positive conclusions. This paper provides a possible protocol for two-stage experiments and a method for adjusting P values. It is shown that, for experiments with reasonable power (>80%), the expected reduction in animal numbers will be at least 20%.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Animais de Laboratório
Limite:
Animals
Idioma:
En
Revista:
Lab Anim
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido