ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo.
Vitam Horm
; 70: 281-307, 2005.
Article
em En
| MEDLINE
| ID: mdl-15727808
ABSTRACT
Nuclear receptors (NRs) are ligand-dependent transcription factors that mediate transcription of target genes in chromatin. Modulation of chromatin structure plays an important part in the NR-mediated transcription process. ATP-dependent chromatin remodeling complexes have been shown to be intimately involved in NR-mediated transcription. In this review, we examine the role of chromatin remodeling complexes in facilitating the recruitment of coregulators and basal transcription factors. In addition, the role of subunit specificity within the chromatin remodeling complexes, the complexes' influence on remodeling activity, and complexes' recruitment to the NR-responsive promoters are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Cromatina
/
Trifosfato de Adenosina
/
Receptores Citoplasmáticos e Nucleares
Idioma:
En
Revista:
Vitam Horm
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos