Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma.
Leukemia
; 19(5): 856-61, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15744341
ABSTRACT
Two microarray studies of mediastinal B cell lymphoma have shown that this disease has a distinct gene expression profile, and also that this is closest to the pattern seen in classical Hodgkin's disease. We reported previously an immunohistologic study in which the loss of intracellular B cell-associated signaling molecules in Reed-Sternberg cells was demonstrated, and in this study we have investigated the expression of the same components in more than 60 mediastinal B cell lymphomas. We report that these signaling molecules are frequently present, and in particular that Syk, BLNK and PLC-gamma2 (absent from Reed-Sternberg cells) are present in the majority of mediastinal B cell lymphomas. The overall pattern of B cell signaling molecules in this disease is therefore closer to that of diffuse large B cell lymphoma than to Hodgkin's disease, and is consistent with a common cell of origin as an explanation of the similar gene expression profiles.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipases Tipo C
/
Fosfoproteínas
/
Proteínas Tirosina Quinases
/
Doença de Hodgkin
/
Proteínas de Transporte
/
Linfoma de Células B
/
Linfoma Difuso de Grandes Células B
/
Precursores Enzimáticos
/
Neoplasias do Mediastino
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Leukemia
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido