Regional variation of airway hyperresponsiveness in children with asthma.
Respir Med
; 99(4): 403-7, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15763445
ABSTRACT
Families with asthmatic children were recruited to take part in a multi-centre collaborative study into the genetics of asthma. Detailed phenotypic information was collected on all family members including lung function, anthropomorphic measurements, response to methacholine challenge, skin prick testing, serum IgE measurements and a detailed nurse-administered questionnaire. Families were eligible for entry into the study if they had two children with a doctor-diagnosis of asthma. Bennett/Twin nebulisers were supplied to each centre from a single source and these were calibrated to determine gravimetric nebuliser output prior to use. Asthmatic probands from each centre had similar degrees of asthma severity and atopy. There was no significant difference in the sex ratios or ages of the probands or numbers of parents with a history of smoking in the families recruited at each centre. However, there was a significant difference in the number of children with airway hyperresponsiveness, with 90% of the North Staffordshire group but only 60% of the Sheffield group having a PC20 of <8 mg/ml for methacholine. This difference highlights the difficulty of using families from different centres in genetic and epidemiological studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Hiper-Reatividade Brônquica
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Respir Med
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido