Radiometallation of receptor-specific peptides for diagnosis and treatment of human cancer.
In Vivo
; 19(1): 9-29, 2005.
Article
em En
| MEDLINE
| ID: mdl-15796153
ABSTRACT
Radiolabeled, receptor-specific peptides are becoming increasingly popular as targeting vectors for the design and development of new diagnostic and therapeutic radiopharmaceuticals. The over-expression of functioning receptors on a variety of human cancers makes this method of drug development a viable tool for tumor targeting in vivo. This review describes some of the more recent efforts that are currently underway towards development of new receptor-specific radiopharmaceuticals. Diagnostic/therapeutic radionuclides, specific metal co-ordinating ligands/chelating systems, spacer technology, radiolabeling protocols, and specific peptides/peptide conjugates will be discussed in detail.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Radioisótopos
/
Receptores de Peptídeos
/
Hormônios Peptídicos
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Animals
/
Humans
Idioma:
En
Revista:
In Vivo
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos