[Hypogammaglobulinemia and thymoma (Good's syndrome): a case report and a literature review]. / Ipogammaglobulinemia associata a timoma (sindrome di Good): descrizione di un caso clinico e revisione della letteratura.
Ann Ital Med Int
; 20(1): 58-61, 2005.
Article
em It
| MEDLINE
| ID: mdl-15859397
ABSTRACT
Good's syndrome is a rare adult-onset immunodeficiency disease characterized by hypogammaglobulinemia and thymoma. A 61-year-old male patient was diagnosed with Good's syndrome after a 2-year history of recurrent respiratory infections. Chest X-ray and chest computed tomography scan showed a mediastinal mass which was surgically removed. Histology revealed a thymoma. Following surgery he presented with recurrent respiratory and urinary tract infections and with esophageal candidiasis, even though his overall conditions dramatically improved after starting treatment with an appropriate dosage of intravenous immunoglobulins. Laboratory tests showed hypogammaglobulinemia, mild neutropenia, lymphopenia with no B cells, decreased CD4+ lymphocytes with an inverted CD4/CD8 ratio and increased interleukin-4-producing CD4+ lymphocytes, suggestive of an excessive Th2 response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timoma
/
Neoplasias do Timo
/
Agamaglobulinemia
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
/
Male
/
Middle aged
Idioma:
It
Revista:
Ann Ital Med Int
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2005
Tipo de documento:
Article