Extension of murine life span by overexpression of catalase targeted to mitochondria.
Science
; 308(5730): 1909-11, 2005 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-15879174
ABSTRACT
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and maximum life spans were maximally increased (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the development of mitochondrial deletions was reduced. These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Catalase
/
Espécies Reativas de Oxigênio
/
Desoxiguanosina
/
Peróxido de Hidrogênio
/
Longevidade
/
Mitocôndrias
/
Mitocôndrias Cardíacas
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos