A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction.
Eur Urol
; 48(2): 303-8, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-15963632
ABSTRACT
OBJECTIVE:
We provide a historical perspective of the P2X receptor class in bladder physiology and the pathophysiology of urinary dysfunction.METHODS:
A literature search was performed using the MEDLINE database.RESULTS:
Evidence suggests that P2X receptors serve a combined function in sensory and motor activity of human bladder. P2X receptors mediate excitation of sensory neurons and evoke muscle contraction in response to ATP release. Anatomical and functional defects in the P2X receptor signaling are associated with a variety of urologic diseases.CONCLUSION:
Current research underscores the importance of P2X receptors in urologic physiology. Potential applications exist in relation to the diagnosis and treatment of urinary dysfunction. However, the detailed mechanism of P2X receptor function in bladder physiology and in urinary tract disease remains unknown and warrants further investigation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Urinário
/
Fenômenos Fisiológicos do Sistema Urinário
/
Receptores Purinérgicos P2
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur Urol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos