Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Science
; 309(5731): 131-3, 2005 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-15994557
ABSTRACT
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Protozoários
/
Theileria parva
/
Theileria annulata
/
Genoma de Protozoário
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido