Eicosanoids, but not tachykinins, excite C-fiber endings in rat sciatic nerve-end neuromas.
Neuroreport
; 3(1): 21-4, 1992 Jan.
Article
em En
| MEDLINE
| ID: mdl-1611031
ABSTRACT
Normal nociceptors are sensitized by hyperalgesic mediators such as eicosanoids and tachykinins. The possibility that these mediators contribute to hyperalgesic pain associated with neural injury was investigated by examining their effects on the excitability of injured afferent nerve endings. In amounts that sensitize normal nociceptors and are hyperalgesic in normal skin, the eicosanoids prostaglandin I2 (PGI2), and 8(R),15(S)-dihydroxyicosatetraenoic acid (8(R),15(S)-diHETE) both excited some C-fibers in chronic neuromas of rat sciatic nerve. In contrast, the selective tachykinin-receptor agonists septide and senktide did not excite C-fibers. None of the mediators affected A-fibers. We conclude that PGI2 and 8(R),15(S)-diHETE may contribute to post-injury pain and hyperalgesia by an action on injured afferent endings.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
/
Taquicininas
/
Eicosanoides
/
Terminações Nervosas
/
Fibras Nervosas
/
Neoplasias do Sistema Nervoso
/
Neuroma
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Israel