Loss-of-function mutations in a glutathione S-transferase suppress the prune-Killer of prune lethal interaction.
Genetics
; 172(1): 207-19, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16143620
ABSTRACT
The prune gene of Drosophila melanogaster is predicted to encode a phosphodiesterase. Null alleles of prune are viable but cause an eye-color phenotype. The abnormal wing discs gene encodes a nucleoside diphosphate kinase. Killer of prune is a missense mutation in the abnormal wing discs gene. Although it has no phenotype by itself even when homozygous, Killer of prune when heterozygous causes lethality in the absence of prune gene function. A screen for suppressors of transgenic Killer of prune led to the recovery of three mutations, all of which are in the same gene. As heterozygotes these mutations are dominant suppressors of the prune-Killer of prune lethal interaction; as homozygotes these mutations cause early larval lethality and the absence of imaginal discs. These alleles are loss-of-function mutations in CG10065, a gene that is predicted to encode a protein with several zinc finger domains and glutathione S-transferase activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Supressão Genética
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Núcleosídeo-Difosfato Quinase
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Proteínas de Drosophila
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Drosophila melanogaster
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Genes Letais
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Glutationa Transferase
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Mutação
Limite:
Animals
Idioma:
En
Revista:
Genetics
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos