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Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas.
Mawrin, Christian; Kirches, Elmar; Diete, Sabine; Wiedemann, Falk R; Schneider, Thomas; Firsching, Raimund; Kropf, Siegfried; Bogerts, Bernhard; Vorwerk, Christian K; Krüger, Sabine; Dietzmann, Knut.
Afiliação
  • Mawrin C; Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany. christian.mawrin@medizin.uni-magdeburg.de
Cancer Lett ; 239(2): 239-45, 2006 Aug 08.
Article em En | MEDLINE | ID: mdl-16198476
The FGFR4 codon 388 polymorphism (Arg(388), Arg/Gly(388) or Gly(388)) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles. Arg(388) was rare in AA, GBM, muscles, and was absent in DA. The Arg/Gly(388) and the Gly(388) frequency was equal among GBM and controls. FGFR4 expression was not related to codon 388 in GBM, and no survival differences between Arg/Gly(388) and Gly(388) tumors were found. U87 cells (Arg/Gly(388)) did not show higher invasion than U138 cells (Gly(388)). This suggests that the FGFR4 codon 388 status does not play a major role in malignant gliomas.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Códon / Polimorfismo de Nucleotídeo Único / Receptor Tipo 4 de Fator de Crescimento de Fibroblastos / Glioma Limite: Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Alemanha
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Códon / Polimorfismo de Nucleotídeo Único / Receptor Tipo 4 de Fator de Crescimento de Fibroblastos / Glioma Limite: Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Alemanha