Postoperative concomitant chemoradiotherapy in locally advanced rectal cancer.
Hepatogastroenterology
; 52(65): 1411-5, 2005.
Article
em En
| MEDLINE
| ID: mdl-16201085
ABSTRACT
BACKGROUND/AIMS:
To gain maximal effectiveness while decreasing toxicity by giving 5-fluorouracil for 45 minutes starting just within 5 minutes after the completion of radiotherapy thrice weekly.METHODOLOGY:
Thirty-eight patients with locally advanced rectal cancer were enrolled in the study. Ranges of total radiation doses were between 50.4 Gy and 61.2 Gy with a median of 59.4 Gy with fraction size of 1.8 Gy five times weekly. 5-fluorouracil was administered thrice weekly with the dose of 250-300mg/m2/day concomitantly with radiation therapy.RESULTS:
Median follow-up time was 30 months. Administration of chemotherapy concomitant with radiotherapy (p=0.089), AJCC stage III (p=0.079), Duke's stage C (p=0.079), presence of lymph node involvement (p=0.079) and presence of local recurrence (p=0.066) appeared to be effecting distant metastasis although differences did not reach statistically significance. Mean overall survival was 46 months in patients without any distant metastasis (SD 3.28; 95% CI 39.46 and 52.31) while it was 35 months in patients with distant metastasis (SD 5.71; 95% CI 23.52 and 45.90, p=0.016).CONCLUSIONS:
Our results have provided further evidence of the ability of postoperative chemoradiotherapy to delay and prevent local recurrence and metastasis of rectal cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
/
Fluoruracila
/
Antimetabólitos Antineoplásicos
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Turquia