Biotransformation of 6beta-santonin by Phytolacca acinosa cell suspension cultures.
Yao Xue Xue Bao
; 40(9): 834-7, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16342687
ABSTRACT
AIM:
To obtain more valuable derivatives for the further structural modification of 6beta-santonin (1) via biotransformation by using cell suspension cultures of Phytolacca acinosa.METHODS:
The substrate 1 was incubated with cell suspension cultures of P. acinosa, the products were obtained by chromatography, and identified on the basis of their physical and spectral data (HRMS, 1D NMR, 2D NMR, NOE and IR).RESULTS:
After incubation with cell suspension cultures of P. acinosa, 1 was converted into five products. Among them, 3 is a new compound.CONCLUSION:
6beta-santonin could be selectively reduced and hydroxylated by the cell suspension cultures of P. acinosa, which would provide valuable intermediates for its further structural modification.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Santonina
/
Phytolacca
Idioma:
En
Revista:
Yao Xue Xue Bao
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China