Identification of the target self-antigens in reperfusion injury.
J Exp Med
; 203(1): 141-52, 2006 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-16390934
ABSTRACT
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
/
Imunoglobulina M
/
Traumatismo por Reperfusão
/
Miosina não Muscular Tipo IIA
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos