Monoclonal antibodies to the nonpeptide angiotensin II receptor antagonist, losartan.
Eur J Pharmacol
; 226(2): 179-82, 1992 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-1639114
ABSTRACT
Two murine monoclonal antibodies were produced to losartan (DuP 753), a nonpeptide angiotensin II receptor antagonist. Using a solid phase competitive enzyme-linked immunosorbent assay (ELISA), each antibody was examined for its ability to bind to a set of losartan analogs that differ structurally in varying degrees. Both antibodies distinguished fine structural changes in the analogs, particularly at the R5 position of the imidazole ring. No cross-reactivity towards either antibody was observed with the natural ligand angiotensin II, the peptide antagonist saralasin, or the AT2 selective nonpeptide antagonist PD123177.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tetrazóis
/
Compostos de Bifenilo
/
Angiotensina II
/
Antagonistas de Receptores de Angiotensina
/
Imidazóis
/
Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article