Class 2 integron-associated antibiotic resistance in Shigella sonnei isolates in Dakar, Senegal.
Int J Antimicrob Agents
; 27(3): 267-70, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16455233
ABSTRACT
Forty-three Shigella sonnei isolates from adult patients with diarrhoea in Dakar were analysed for the presence of integrons. Isolates were resistant to sulphamethoxazole, trimethoprim, tetracycline, streptomycin and spectinomycin. A high prevalence of class 2 integrons (93%) was found. These integrons showed three distinct structures a class 2 integron, part of the Tn7 family and its derivatives, carrying four cassettes in the order dfrA1-sat-aadA1-orfX; a truncated class 2 integron, without orfX; and a third type ca. 4 kb in size. These class 2 integrons probably play a role in the spread of multiresistance in S. sonnei isolates. To our knowledge, this is the first description of class 2 integrons in S. sonnei isolated in sub-Saharan Africa.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Shigella sonnei
/
Farmacorresistência Bacteriana
/
Integrons
/
Antibacterianos
Tipo de estudo:
Prevalence_studies
Limite:
Adult
/
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
Int J Antimicrob Agents
Ano de publicação:
2006
Tipo de documento:
Article