Detection of Epstein-Barr virus sequences in primary brain lymphoma without immunodeficiency.
Neurology
; 41(7): 1152-3, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1648683
ABSTRACT
We searched for Epstein-Barr virus (EBV) sequences by enzymatic DNA amplification in nine primary brain lymphomas from patients without immunodeficiency. We used seven nonlymphoma brain tumors as negative controls, and the Raji cell line as a positive control. We detected EBV DNA, using ethidium bromide-stained-agarose minigel electrophoresis and dot blot hybridization, in the positive control and in only one brain lymphoma tumor; we did not detect EBV DNA in the other tumors. The EBV-positive patient had a second B-cell monoclonal population in the peripheral blood without detectable EBV DNA, suggesting a direct role for EBV in the development of the brain lymphoma.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
DNA Viral
/
Herpesvirus Humano 4
/
Tolerância Imunológica
/
Linfoma
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Neurology
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
França