Successful treatment of CCL4-induced acute liver failure with portal vein arterialization in the rat.
Transplant Proc
; 38(4): 1187-9, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16757302
ABSTRACT
INTRODUCTION:
Optimization of the conditions for regeneration of the native diseased liver is a major goal in patients with acute liver failure. This study sought to determine whether portal vein arterialization (PVA), which increases the oxygen supply to the liver, was protective in a rat model of liver failure.METHODS:
At 24 hours after CCl(4) intoxication, Sprague-Dawley rats (six per group) were assigned to receive PVA or as controls. We determined blood tests, histology, and 10-day survivals. Hepatocyte regeneration was assessed by the mitotic index and bromodeoxyuridine (BrdU) incorporation.RESULTS:
Serum transaminases were significantly lower in PVA-treated rats than in control animals liver necrosis resolved rapidly after PVA. The BrdU staining and mitotic index were severalfold higher among PVA-treated than in untreated rats. Survival was 100% among rats with PVA and 40% in untreated animals (P < .01).CONCLUSIONS:
PVA led to resolution of CCl(4)-induced massive liver necrosis in the rat. This effect was probably mediated by activation of rapid and extensive hepatocyte regeneration. PVA might provide a novel, alternative approach to treat acute liver failure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Veia Porta
/
Intoxicação por Tetracloreto de Carbono
/
Falência Hepática
/
Circulação Hepática
Limite:
Animals
Idioma:
En
Revista:
Transplant Proc
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália