Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice.
Neuron
; 7(1): 59-68, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1676894
ABSTRACT
Prolonged incubation times for experimental scrapie in I/LnJ mice are dictated by a dominant gene linked to the prion protein gene (Prn-p). Transgenic mice were analyzed to discriminate between an effect of the I/LnJ Prn-pb allele and a distinct incubation time locus designated Prn-i. Paradoxically, 4 independent Prn-pb transgenic mouse lines had scrapie incubation times shorter than nontransgenic controls, instead of the anticipated prolonged incubation periods. Aberrant or overexpression of the Prn-pb transgenes may dictate abbreviated incubation times, masking genuine Prn-p/Prn-i congruence; alternatively, a discrete Prn-i gene lies adjacent to Prn-p.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Scrapie
/
Proteínas Virais
/
Expressão Gênica
Limite:
Animals
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1991
Tipo de documento:
Article