Alcoholic abstinence syndrome: short-term treatment with metadoxine.
Int J Clin Pharmacol Res
; 11(1): 35-40, 1991.
Article
em En
| MEDLINE
| ID: mdl-1678735
ABSTRACT
The effects of metadoxine (pyrrolidone carboxylate of pyridoxine), a compound with central benzodiazepine-like properties, were evaluated in two groups of chronic alcoholics (inpatients) presenting a mild withdrawal syndrome. According to a double-blind study design 20 patients received metadoxine 900 mg twice daily eluted in 500 ml of saline infusion, while 20 (the control group) were given 500 ml of saline infusion twice daily with equivalent doses of pyridoxine (40 mg/die) every morning over a 10-day period. The results indicate that metadoxine treatment was able to control alcohol abstinence, thus allowing a reduction in the needs for standard benzodiazepine therapy. The central activity of gamma-aminobutyric acid of this compound might play a crucial role in the clinical effects demonstrated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridoxina
/
Ácido Pirrolidonocarboxílico
/
Síndrome de Abstinência a Substâncias
/
Etanol
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Clin Pharmacol Res
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Itália