A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests.
Eur J Med Chem
; 41(10): 1196-200, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16828526
ABSTRACT
A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2-(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasii, although it had a high level of mutagenicity, as observed in mutagenic activity tests.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Mycobacterium kansasii
/
Mycobacterium avium
/
Nitrocompostos
/
Antituberculosos
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil