Clinical phenotype of an Italian family with a new mutation in the PRPF8 gene.
Eur J Ophthalmol
; 16(5): 779-81, 2006.
Article
em En
| MEDLINE
| ID: mdl-17061239
ABSTRACT
PURPOSE:
To report the clinical and functional characteristics of an autosomal dominant retinitis pigmentosa (ADRP) family with a novel point mutation (P2301S) in the PRPF8 gene.METHODS:
PRPF8 gene analysis and complete ophthalmologic examination in an ADRP family.RESULTS:
Clinical examination revealed the typical RP phenotype in all family members. Electroretinography showed preserved ERG photopic responses. Genetic analysis showed that the P2301S missense mutation segregated with the disease in all subjects.CONCLUSIONS:
Unlike previously reported families, the PRPF8 gene mutation in our family is associated with a mild phenotype in which cone function is partially preserved.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Proteínas de Transporte
/
Retinose Pigmentar
/
Mutação
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Eur J Ophthalmol
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália