Radionecrosis or tumor recurrence after radiation of laryngeal and hypopharyngeal carcinomas.
Otolaryngol Head Neck Surg
; 135(6): 838-43, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17141070
ABSTRACT
OBJECTIVE:
To analyze the incidence and diagnostic difficulties of radionecrosis vs tumor recurrence of laryngeal and hypopharyngeal carcinomas. STUDY DESIGN ANDSETTING:
Retrospective study on 341 patients treated by radiation alone or radiochemotherapy. The clinicopathologic findings, work-up, treatment, and follow-up of 20 patients with symptoms suggestive but negative for tumor recurrence on initial imaging studies and endoscopy were analyzed.RESULTS:
The incidence of chondroradionecrosis in 341 irradiated patients was 5%. Ten of 20 patients initially negative for tumor recurrence were treated by total laryngectomy; in all laryngectomy specimens, chondroradionecrosis was present, in six specimens associated with tumor recurrence. Ten patients were treated by tracheotomy and tumor recurrence was detected in one patient during follow-up.CONCLUSION:
Chondroradionecrosis is a relatively rare treatment complication. Typical imaging findings suggestive of radionecrosis are often missing. Tumor recurrence may be present beneath an intact mucosa and missed by endoscopy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Neoplasias Hipofaríngeas
/
Neoplasias Laríngeas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Suíça