Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug.
J Pharm Pharmacol
; 43(6): 450-4, 1991 Jun.
Article
em En
| MEDLINE
| ID: mdl-1717675
ABSTRACT
Microemulsions with a 5842 weight ratio of dioctyl sodium sulphosuccinate octanol and containing 15, 35, and 68% water have been tested for their ability to transport glucose across human cadaver skin. A flow-through multisample skin diffusion cell showed that both the 35 and 68% water microemulsions caused enhanced (approximately 30-fold) transport of glucose. No transport was discernible for the 15% water microemulsion. Differences in percutaneous glucose transport were shown to parallel differences in the diffusion of water within the microemulsion vehicles before application to the skin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Absorção Cutânea
/
Ácido Dioctil Sulfossuccínico
/
Emulsões
Limite:
Humans
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article