Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma.
Pathol Res Pract
; 203(4): 245-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-17317032
Expression of the transforming growth factor-beta (TGF-beta) protein family in the peripheral nervous system is well established, but the role of their cognate receptors TGF-beta receptor type 1 (R1) and type 2 (R2) has been less well studied. TGF-beta plays an essential role in Schwann cell proliferation and differentiation, and is involved in neurotrophic effects of several neurotrophic substances. TGF-beta is also expressed in benign peripheral nervous system tumors such as vestibular schwannomas. In the present study, we aimed to detect TGF-beta R1 and R2 in a total of 40 sporadic vestibular schwannomas using immunohistochemistry, and correlated the findings to essential clinicopathologic data. TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA was further analyzed by RT-PCR in six vestibular schwannomas. TGF-beta R1 immunoexpression was found in about 95% of the tumors. TGF-beta R1 was equally present in Antoni A and Antoni B areas of the tumors. TGF-beta R2 was found immunohistochemically in 77%. In addition, all tumors showed strong expression of TGF-beta. No correlation between TGF-beta R1 or R2 expression and clinicopathologic parameters such as age, sex, clinical symptoms, growth pattern, and proliferation acitivity as measured by Ki-67 (MIB-1) staining was found. Moreover, all schwannomas studied contained TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA. Therefore, the TGF-beta/TGF-beta R1 and -R2 system is present in human schwannomas, but its biologic role for tumor development and growth remains unclear.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Nervo Vestibulococlear
/
Receptores de Fatores de Crescimento Transformadores beta
/
Neoplasias dos Nervos Cranianos
/
Neurilemoma
Limite:
Humans
Idioma:
En
Revista:
Pathol Res Pract
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha