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Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma.
Löttrich, Mathias; Mawrin, Christian; Chamaon, Kathrin; Kirches, Elmar; Dietzmann, Knut; Freigang, Bernd.
Afiliação
  • Löttrich M; Department of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Pathol Res Pract ; 203(4): 245-9, 2007.
Article em En | MEDLINE | ID: mdl-17317032
Expression of the transforming growth factor-beta (TGF-beta) protein family in the peripheral nervous system is well established, but the role of their cognate receptors TGF-beta receptor type 1 (R1) and type 2 (R2) has been less well studied. TGF-beta plays an essential role in Schwann cell proliferation and differentiation, and is involved in neurotrophic effects of several neurotrophic substances. TGF-beta is also expressed in benign peripheral nervous system tumors such as vestibular schwannomas. In the present study, we aimed to detect TGF-beta R1 and R2 in a total of 40 sporadic vestibular schwannomas using immunohistochemistry, and correlated the findings to essential clinicopathologic data. TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA was further analyzed by RT-PCR in six vestibular schwannomas. TGF-beta R1 immunoexpression was found in about 95% of the tumors. TGF-beta R1 was equally present in Antoni A and Antoni B areas of the tumors. TGF-beta R2 was found immunohistochemically in 77%. In addition, all tumors showed strong expression of TGF-beta. No correlation between TGF-beta R1 or R2 expression and clinicopathologic parameters such as age, sex, clinical symptoms, growth pattern, and proliferation acitivity as measured by Ki-67 (MIB-1) staining was found. Moreover, all schwannomas studied contained TGF-beta, TGF-beta R1, and TGF-beta R2 mRNA. Therefore, the TGF-beta/TGF-beta R1 and -R2 system is present in human schwannomas, but its biologic role for tumor development and growth remains unclear.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Nervo Vestibulococlear / Receptores de Fatores de Crescimento Transformadores beta / Neoplasias dos Nervos Cranianos / Neurilemoma Limite: Humans Idioma: En Revista: Pathol Res Pract Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Nervo Vestibulococlear / Receptores de Fatores de Crescimento Transformadores beta / Neoplasias dos Nervos Cranianos / Neurilemoma Limite: Humans Idioma: En Revista: Pathol Res Pract Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Alemanha