Translesion synthesis: Y-family polymerases and the polymerase switch.
DNA Repair (Amst)
; 6(7): 891-9, 2007 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-17363342
ABSTRACT
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígeno Nuclear de Célula em Proliferação
/
DNA Polimerase Dirigida por DNA
/
Reparo do DNA
/
Replicação do DNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
DNA Repair (Amst)
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido