Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.
Phytother Res
; 21(7): 684-9, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17444577
ABSTRACT
According to folk medicine some species belonging to the genus Cyclamen were used for their biological activities. Early investigation of the different species of the genus resulted in the isolation of triterpenic saponins. No phytochemical and biological data are available on C. repandum. As part of a series of phytochemical investigations for bioactive compounds from medicinal plants, Cyclamen repandum S. et S. was investigated. The present study sought to find the antiinflammatory and antinociceptive activities of C. repandum tubers in rats and mice. A preliminary screening was conducted with three different extracts in the tests used, particularly the paw edema and the writhing tests. Subsequently some saponins isolated from the ME extract, the more effective one, have been identified. This paper also describes the results of fractionation and bioassay guided chemical studies. Chemical investigation of the active extract afforded the isolation and characterization of six triterpenic saponins. The possible antiinflammatory and analgesic properties were investigated as the saponin content of the fractions allows to speculate on such aspect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Extratos Vegetais
/
Cyclamen
/
Edema
/
Analgésicos
/
Fitoterapia
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália