Dietary fat, hypothalamic glutamate decarboxylase, and food intake of streptozotocin-diabetic rats.
Am J Physiol
; 261(6 Pt 2): R1554-9, 1991 Dec.
Article
em En
| MEDLINE
| ID: mdl-1750579
The association among changes in glucose status, glutamate decarboxylase (GAD) activity, and food intake was evaluated in several hypothalamic areas of streptozotocin-diabetic rats fed a low- (12% of calories as fat) or high-fat diet (59% of calories as fat). Control rats consumed approximately 90 kcal/24 h of either diet, whereas diabetic rats consumed approximately 150 kcal/24 h of the low-fat diet and approximately 100 kcal/24 h of the high-fat diet. At the end of the study, diabetic rats fed the high-fat diet weighed more and had higher retroperitoneal fat depot weights (P less than 0.05) than diabetic rats fed the low-fat diet. In diabetic rats, GAD activity was 15-20% higher in the ventromedial nucleus (P less than 0.01) but similar to controls in the lateral hypothalamus, paraventricular nucleus, and area postrema. Diet did not affect GAD activity in the brain areas studied. The increase in ventromedial nucleus GAD activity was not associated with the level of food intake and was the likely result of altered glucose homeostasis in diabetic rats.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gorduras na Dieta
/
Diabetes Mellitus Experimental
/
Ingestão de Alimentos
/
Glutamato Descarboxilase
/
Hipotálamo
Limite:
Animals
Idioma:
En
Revista:
Am J Physiol
Ano de publicação:
1991
Tipo de documento:
Article