Anomeric information obtained from a series of synthetic trisaccharides using energy resolved mass spectra.
J Mass Spectrom
; 42(6): 714-23, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17511018
ABSTRACT
The majority of structural investigations of oligosaccharides based on mass spectrometry use naturally occurring oligosaccharides, which do not allow extracting any common feature associated with anomeric structures and linkage positions. In order to address the issue to find such characteristics possibly contained in oligosaccharide structure, a synthetic combinatorial trisaccharide library was analyzed. The trisaccharides used in the analysis consisted of L-fucose, D-galactose and D-glucose, in which individual glycosidic linkages existed in either alpha- or beta-anomers. The analysis of energy-resolved mass spectra (ERMS) and the scattered plot analysis of some parameters obtained from ERMS for a series of trisaccharides revealed that lower activation energy was required for the dissociation of alpha-glycosides of these sugars compared to those of the corresponding beta-anomers. It is suggested that this finding may be useful in structural analysis of natural oligosaccharides.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trissacarídeos
/
Espectrometria de Massas por Ionização por Electrospray
Idioma:
En
Revista:
J Mass Spectrom
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão