Lactoferrin from canine neutrophils: isolation and physicochemical and antimicrobial properties.
Biochemistry (Mosc)
; 72(4): 445-51, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17511610
ABSTRACT
Lactoferrin has been isolated from canine leukocytes for the first time. Lactoferrin was identified by N-terminal amino acid sequence and by capability to capture ferric cations resulting in a complex with absorbance maximum at 460-470 nm. It is demonstrated that canine lactoferrin resembles the human homolog in some physicochemical properties, i.e. molecular weight, carbohydrate presence, and conditions of protein-iron complex dissociation. Bactericidal activity of dog lactoferrin was demonstrated on the gram-negative bacterium Escherichia coli and gram-positive bacterium Listeria monocytogenes. Bactericidal activity of canine lactoferrin is similar to that of human lactoferrin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lactoferrina
/
Anti-Infecciosos
/
Neutrófilos
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Federação Russa