Effect of formoterol on allergen-induced cytokine synthesis by atopic asthmatics.
Int Arch Allergy Immunol
; 143 Suppl 1: 106-9, 2007.
Article
em En
| MEDLINE
| ID: mdl-17541287
ABSTRACT
BACKGROUND:
Effect of formoterol, long-acting beta(2 )agonists, on T cell cytokine synthesis was examined.METHODS:
Human peripheral blood mononuclear cells were obtained from atopic asthmatics, and stimulated with Dermatophagoidesfarinae extract. Various concentrations of formoterol were added from the start of some cultures. Cytokine production and cell proliferation were analyzed.RESULTS:
Allergen-induced IL-5, IL-13, and IFN-gamma production of PBMC were significantly suppressed by formoterol in a dose-dependent manner, whereas the proliferation response was not suppressed.CONCLUSION:
Formoterol downregulates T cell functions of atopic asthmatics in vitro.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Leucócitos Mononucleares
/
Regulação para Baixo
/
Regulação da Expressão Gênica
/
Interleucina-5
/
Interferon gama
/
Agonistas Adrenérgicos beta
/
Interleucina-13
/
Antígenos de Dermatophagoides
/
Etanolaminas
Limite:
Adult
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int Arch Allergy Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão