Caenorhabditis elegans SDF-9 enhances insulin/insulin-like signaling through interaction with DAF-2.
Genetics
; 177(1): 661-6, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17660545
ABSTRACT
SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Receptor de Insulina
/
Transdução de Sinais
/
Proteínas Tirosina Fosfatases
/
Caenorhabditis elegans
/
Proteínas de Caenorhabditis elegans
/
Insulina
Limite:
Animals
Idioma:
En
Revista:
Genetics
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Canadá