PS1 expression is downregulated by gonadal steroids in adult mouse brain.
Neurochem Res
; 33(3): 365-9, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-17703361
ABSTRACT
Mutations in presenilin (PS) 1 and PS2 genes are associated with early onset (< or =65 years) of Alzheimer's disease (AD). PS1 is involved in gamma-secretase mediated cleavage of beta-amyloid precursor protein (APP), but its regulation is poorly understood. Sex steroids influence APP cleavage pathways resulting in reduced burden of both intra- and extra-cellular nonamyloidogenic products. As gonadal hormones are implicated in AD and their levels change with age, we have analyzed the effect of 17beta-estradiol and testosterone on PS1 expression in the cerebral cortex of adult and old AKR mice of both sexes. Northern and Western-blot analysis revealed that PS1 mRNA and protein expression followed similar pattern of regulation. PS1 expression was downregulated by 17 beta-estradiol and testosterone in the cerebral cortex of females and adult male, but upregulated in old male mice. Such sex-dependent regulation of PS1 expression during aging by gonadal steroids might account for the PS-related brain functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios Esteroides Gonadais
/
Química Encefálica
/
Presenilina-1
Limite:
Animals
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Índia