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Variant CYP2C9 alleles and warfarin concentrations in patients receiving low-dose versus average-dose warfarin therapy.
Redman, Andrea R; Zheng, Jack; Shamsi, Shahab A; Huo, Jingguo; Kelly, Edward J; Ho, Rodney J Y; Ritchie, Denise M; Hon, Yuen Yi.
Afiliação
  • Redman AR; Pharmacy Department, Rockdale Medical Center, Conyers, GA 30012, USA. Andrearredman@yahoo.com
Clin Appl Thromb Hemost ; 14(1): 29-37, 2008 Jan.
Article em En | MEDLINE | ID: mdl-17895500
This study compared the frequency of variant cytochrome P450 2C9 (CYP2C9) alleles and warfarin S/R concentration ratio in patients who required low-dose (<2.5 mg/day) and average-dose (5+/-0.5 mg/day) warfarin. Patients who achieved a therapeutic international normalized ratio were recruited from the Atlanta Veterans Affairs Medical Center anticoagulation clinic. CYP2C9*2 and *3 alleles were determined by validated Taqman allelic discrimination assays. Warfarin S and R concentrations were determined by chiral capillary electrochromatography with electrospray ionization mass spectrometry. At least 1 variant allele was found in 66.7% and 22.2% of patients in the low-dose and average-dose groups, respectively (P= .001, chi(2)). The warfarin S/R concentration ratio was 0.665 (range, 0.162-3.58) and 0.452 (range, 0.159-2.36) for patients receiving low-dose and average-dose therapy, respectively (P= .097). A warfarin requirement of <2.5 mg/day and an elevated warfarin S/R concentration ratio were each associated with a higher frequency of variant CYP2C9 alleles.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Variação Genética / Varfarina / Hidrocarboneto de Aril Hidroxilases Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Appl Thromb Hemost Assunto da revista: ANGIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Variação Genética / Varfarina / Hidrocarboneto de Aril Hidroxilases Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Appl Thromb Hemost Assunto da revista: ANGIOLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos