The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo.
Development
; 113(4): 1105-14, 1991 Dec.
Article
em En
| MEDLINE
| ID: mdl-1811930
ABSTRACT
The differentiation in vitro of murine embryonic stem cells to embryoid bodies mimics events that occur in vivo shortly before and after embryonic implantation. We have used this system, together with differential cDNA cloning, to identify genes the expression of which is regulated during early embryogenesis. Here we describe the isolation of several such cDNA clones, one of which corresponds to the gene H19. This gene is activated in extraembryonic cell types at the time of implantation, suggesting that it may play a role at this stage of development, and is subsequently expressed in all of the cells of the mid-gestation embryo with the striking exception of most of those of the developing central and peripheral nervous systems. After birth, expression of this gene ceases or is dramatically reduced in all tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Células-Tronco
/
Expressão Gênica
/
Desenvolvimento Embrionário e Fetal
Limite:
Animals
Idioma:
En
Revista:
Development
Assunto da revista:
BIOLOGIA
/
EMBRIOLOGIA
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido