[Preparation of sinomenine microemulsion and its transdermal absorption].
Zhongguo Zhong Yao Za Zhi
; 32(19): 2007-10, 2007 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-18161292
ABSTRACT
OBJECTIVE:
To screen the optimum formulation and prepare O/W sinomenine microemulsion and investigate its in vitro transdermal delivery ability.METHOD:
The microemulsions were prepared with the formulation containing oleic acid-tween 80-dehydrated alcohol-water by the pseudo-ternary phase diagram. The permeation flux of sinomenine was determined in vitro by Franz diffusion cell fitted with rat skin. The sinomenine was determined by HPLC. The transdermal characteristics of sinomenine microemulsion were compared with that of sinomenine gels.RESULT:
The steady state flux of sinomenine microemulsion was significantly higher than that of sinomenine gels. The average permeation rate of sinomenine microemulsion was 116. 44 microg x cm(-2) x h(-1) in vitro.CONCLUSION:
These results indicated that the studied microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of sinomenine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Absorção Cutânea
/
Composição de Medicamentos
/
Morfinanos
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China