Patterns of quantitative food-specific IgE-antibodies and reported food hypersensitivity in 4-year-old children.
Allergy
; 63(4): 418-24, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18162084
ABSTRACT
BACKGROUND:
Diagnosis of food hypersensitivity (FHS) is difficult and interpretation of food allergy tests is complicated.OBJECTIVE:
To investigate the probability of reported FHS in relation to levels of food-specific IgE-antibodies (AB) in a population-based setting of 4-year-old children (n = 2336).METHODS:
Information on FHS was obtained from a questionnaire and specific IgE-AB to milk, egg, fish, peanut, soy and wheat were analysed.RESULTS:
Thirty-one per cent of the children with reported FHS (n = 284) were sensitized (> or =0.35 kU(A)/l) to at least one of the tested foods compared with 11% of children without FHS (n = 2052). Furthermore, the probability of reported symptoms to milk, egg and fish increased with increasing levels of food-specific IgE-AB to the same food allergens. A similar trend was seen for peanut and wheat, but not for soy. Increasing levels of specific IgE-AB to milk or egg were also associated with an increasing risk of reported symptoms caused by other foods.CONCLUSIONS:
Quantitative measurements of IgE-AB to milk, egg and fish are useful to evaluate IgE-associated FHS in preschool children also in a population based sample. Such measurements appear to be of limited value for soy bean and wheat, in particular as a screening method.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Hipersensibilidade Alimentar
Limite:
Animals
/
Child, preschool
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Allergy
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Suécia