[The effect of nifedipine on pulmonary hemodynamics after injection of oleic acid in rabbits].
Zhonghua Jie He He Hu Xi Za Zhi
; 14(6): 347-9, 377, 1991 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-1818776
ABSTRACT
Twelve rabbits were divided into two groups, A control group; B nifedipine group. Oleic acid (0.1 ml/kg) was injected into pulmonary arteries of 12 rabbits. Nifedipine (1 mg/kg) was given sublingually before oleic acid injected in B group. The results showed that the pulmonary vascular resistance (PVR), pulmonary artery pressure (PAP) were obviously increased and cardiac output (CO) heart rate (HR) decreased in two groups (P less than 0.05, P less than 0.01, P less than 0.001). The degree of increase of PVR, and the degree of decrease of CO were obviously less in B group than that of A group (P less than 0.05, P less than 0.01, P less than 0.001 in different periods). The results showed that nifedipine improved pulmonary hemodynamics of pulmonary damage by oleic acid.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nifedipino
/
Circulação Pulmonar
Limite:
Animals
Idioma:
Zh
Revista:
Zhonghua Jie He He Hu Xi Za Zhi
Ano de publicação:
1991
Tipo de documento:
Article