Relation between elevated high-sensitivity C-reactive protein and anti-mitochondria antibody in patients with systemic sclerosis.
J Dermatol
; 35(2): 70-5, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18271801
ABSTRACT
Systemic sclerosis (SSc) is a systemic connective tissue disease of unknown etiology which presents immunological, vascular and connective tissue abnormalities. C-reactive protein (CRP) has been used for the evaluation of inflammation in patients with infection and inflammatory diseases. Recently, high-sensitivity CRP has been shown to reflect mild and/or moderate inflammation for the prognosis of ischemic heart disease. High-sensitivity CRP was measured for the evaluation of mild and/or moderate inflammation in SSc. Forty SSc patients (male female, 733; age, 16-78 years; mean, 61.9 years) were studied. High-sensitivity CRP was measured with a nephelometric assay. The detection limit was 0.0036 mg/dL, linearity from 0.015-1.5 mg/dL. The distribution of high-sensitivity CRP showed 26 cases (65.0%) low, three cases (7.5%) mild, four cases (10.0%) moderate, four cases (10.0%) high and three cases (7.5%) highest. The occurrence rate of anti-mitochondria antibody in high-sensitivity CRP elevated SSc patients (8/14, 57.1%) was significantly elevated compared with that of high-sensitivity CRP low SSc patients (3/26, 11.5%) (P < 0.01). These results led us to the conclusion that elevated high-sensitivity CRP shows relation to the occurrence of anti-mitochondria antibody.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
/
Proteína C-Reativa
/
Mitocôndrias
/
Anticorpos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adolescent
/
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Dermatol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão