[Role of insufficient hormone production in development of osteopenia in consequence of physical loads defficiency].
Aviakosm Ekolog Med
; 41(6): 13-7, 2007.
Article
em Ru
| MEDLINE
| ID: mdl-18350830
ABSTRACT
Experiments with rats deprived of support loading on hind limbs by tail-suspension showed that injection of hormones participating in bone metabolism impeded the development of tibial spongy osteopenia; also, normalization of longitudinal bone growth was observed in several cases. Investigations were aimed to evaluate the effectiveness of growth hormone, sex hormones, thyreoid hormones, calcitonin, CNS stimulating ephedrine and strychnine, and graded support loads. The best results were obtained after injection of calcitonin combined with sinestrol (synthetic analog of estradiol) and graded support loads which acted as initiators and amplifiers of hormonal effects. The combination of calcitonin, sinestrol and support loads prevented osteopenia and provided the normal bone growth in length during rat's suspension.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Ósseas Metabólicas
/
Calcitonina
/
Hormônio do Crescimento
/
Dienestrol
/
Estrogênios não Esteroides
/
Conservadores da Densidade Óssea
/
Atividade Motora
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
Ru
Revista:
Aviakosm Ekolog Med
Assunto da revista:
MEDICINA AEROESPACIAL
/
SAUDE AMBIENTAL
Ano de publicação:
2007
Tipo de documento:
Article